Alismatis Rhizoma (Ze xie) Herbal: What It Is, Benefits and More

If you’re curious about traditional Chinese herbs that have piqued the interest of modern researchers, Alismatis Rhizoma might be the next one on your list.

Also referred to as Ze xie(chinese name: 泽泻) or Oriental Waterplantain Tuber, it has a storied history in traditional Chinese medicine (TCM) for managing fluid balance and supporting healthy kidney and bladder function.

Modern studies suggest that it may hold benefits well beyond its classic uses, from supporting heart health to helping regulate cholesterol. Let’s dive in.

What is Alismatis Rhizoma

Alismatis Rhizoma is derived from the tuber of the Alisma orientalis (Sam.) Juzep. plant. It typically grows in marshy environments across parts of China, including Sichuan, Jiangxi, and Fujian. Harvest usually occurs when the plant begins to wither in winter. After washing and drying, the tubers can be sliced and processed in various ways (like salted or roasted with bran) to modify their properties for different therapeutic needs¹.

In TCM, it’s considered sweet, bland, and slightly cold in nature, primarily entering the kidney and bladder meridians. Historically, TCM references like Bencao Gangmu underscore its ability to “drain dampness and clear heat,” a property that has made it popular for treating water retention, edema, and even high lipid levels².

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Active Compounds and Research Highlights

Modern research has found that Alismatis Rhizoma is rich in³:

• Triterpenes (e.g., Alisol A, B, and C acetates)
• Volatile oils
• Alkaloids
• Amino acids (like asparagine)
• Resins

These compounds appear to influence fluid metabolism, cholesterol regulation, and blood pressure control. In particular:

• Triterpenes such as Alisol A and B acetates:
  Shown in animal studies to significantly reduce serum cholesterol—some research indicates up to a 50% decrease in certain experimental settings⁴.
• Diuretic effects:
  Several experiments noted an increased excretion of sodium (Na+) and potassium (K+) when given at specific doses to animals⁵.
• Cardiovascular support:
  Mild blood pressure reduction and a potential protective effect on blood vessels have been observed in preliminary research⁶.

Please note that while these findings are promising, most data come from animal or lab studies, and more human research is needed.

Summary: Modern research shows Alismatis Rhizoma has triterpenes, volatile oils, etc. These compounds may affect fluid, cholesterol, and blood pressure. Triterpenes can lower cholesterol, it has diuretic and cardio – support effects, but more human research is needed.

Health benefits and Medical uses

Below are the main traditional and modern uses associated with Alismatis Rhizoma. Keep in mind that results may vary depending on individual factors, and consulting a licensed professional is always recommended.

1. Promotes Urination and Reduces Edema
   In TCM, Alismatis Rhizoma is frequently used for water retention, bloating, and difficulty urinating. It’s considered especially useful in formulas targeting “damp-heat” symptoms—like swelling, fullness in the abdomen, or cloudy urine⁷.
2. Helps Manage High Cholesterol
   If you read any TCM-based regimen for high lipid levels, you’ll often find Ze xie in the mix. Several animal studies suggest it can help lower total cholesterol and protect against artery blockages⁸.
3. Supports Kidney and Bladder Health
   Because it’s said to enter the kidney and bladder meridians, Alismatis Rhizoma may help drain excess dampness and heat in the lower body, offering possible relief in conditions like urinary tract issues or mild lower back discomfort related to fluid retention⁹.
4. Could Have Mild Liver-Protective Effects
   Some extracts, especially certain triterpenes, show a protective effect on liver tissue when tested in animal models, notably reducing damage from toxic chemicals like carbon tetrachloride¹⁰.
5. Part of Classic TCM Formulas
   You’ll find Ze xie in well-known formulas such as Wu Ling San and Zexie Tang, often combined with herbs like Poria (Fu Ling) and Polyporus (Chu ling) for enhanced diuretic and damp-clearing effects¹¹.

Summary: Alismatis Rhizoma has various health benefits. It promotes urination, reduces edema, manages high cholesterol, supports kidney and bladder health, may protect the liver, and is in classic TCM formulas.

How to Use Alismatis Rhizoma

• Typical Preparation: Most often, Alismatis Rhizoma is boiled (decocted) in water. Typical daily amounts range from 5–10g in a standard TCM prescription¹².
• Processed Forms:
  • Salted Ze xie helps direct the herb’s action to the kidneys and can be beneficial if you struggle with lower-body dampness or heat.
  • Bran-roasted Ze xie (麸炒泽泻) is said to reduce its cold nature and is often used for those with weaker digestion.
• Culinary Uses: Under certain guidelines in Chinese dietary therapy, Ze xie may be added to soups (like with carp, red beans, and winter melon peel) to help reduce fluid retention, but always consult a TCM professional first¹³.

Summary: Alismatis Rhizoma is usually decocted in water, with 5 – 10g daily in TCM prescriptions. Processed forms like salted and bran – roasted have different effects. It may be added to soups for fluid retention, but consult TCM pros first.

Side Effects, Interactions, and Precautions

Like many potent herbs, Alismatis Rhizoma has some considerations¹⁴¹⁵:

1. Possible Digestive Discomfort:
   Overconsumption may lead to diarrhea or abdominal pain—especially in those not accustomed to higher fiber or diuretic herbs.
2. Not for Kidney-Yang Deficiency:
   TCM theory advises avoiding Ze xie if you have “kidney-yang deficiency” or no signs of damp-heat, as its cold and draining nature may worsen certain imbalances.
3. Potential Toxicity with Improper Use:
   The plant’s rootstock contains compounds that can cause numbness or GI upset if used incorrectly. Always rely on reputable suppliers and proper dosages.
4. Drug Interactions:
   If you’re on diuretics or blood pressure medications, talk to a healthcare professional before starting any TCM herb to avoid over-lowering your blood pressure or altering electrolyte levels.
5. Special Populations:
   • Pregnant or Breastfeeding: Safety data in these groups is limited; consult your physician.
   • Children: Use under strict professional supervision only.

Summary: Alismatis Rhizoma has considerations. Overuse may cause digestive issues. Avoid if having kidney – yang deficiency. Improper use can be toxic. Check with doc if on relevant meds. Caution for pregnant, breastfeeding, and children.

Frequently Asked Questions

Q1: Can Alismatis Rhizoma help with weight management?
Yes, it’s commonly used in TCM to reduce water retention¹⁶, which can help if fluid buildup is a contributing factor. However, weight management often requires a comprehensive approach, including diet and exercise Source:TCM−basedclinicalobservationsSource: TCM-based clinical observationsSource:TCM−basedclinicalobservations.

Q2: How do I incorporate Ze xie into my diet safely?
You can brew it into a decoction (5–10g daily) or add it to soups with ingredients like carp and winter melon peel. Make sure to follow a TCM practitioner’s advice to avoid any misuse.

Q3: Are there any herbs or foods to avoid when taking Alismatis Rhizoma?
Yes. Classical sources recommend not combining it with certain shell-derived minerals such as clams (hai ge ke), as they may reduce its efficacy. Also, you might want to limit iron-rich foods (like spinach or seaweed) at the exact same time to prevent interference with the herb’s absorption.

Q4: Could Alismatis Rhizoma replace my prescription diuretic?
Probably not. While it does have diuretic effects, you shouldn’t replace prescribed medications without professional guidance. Combining both without supervision can also lead to electrolyte imbalances.

Q5: Is it okay to use Alismatis Rhizoma for long periods?
Long-term use should be determined by a TCM professional. Overuse of cold-natured herbs like Ze xie might unbalance digestion or cause excessive fluid loss if not closely monitored.

Bottom Line

Alismatis Rhizoma (Ze xie) is a staple in traditional Chinese medicine, traditionally used to promote healthy water metabolism, ease edema, and address damp-heat conditions. Modern studies point toward potential benefits for cholesterol management, kidney and liver protection, and modest blood-pressure support. However, keep in mind that scientific data—particularly from human trials—remains somewhat limited.

If you’re intrigued and want to experience its potential benefits, the best step is to consult a trained TCM practitioner. They can guide you on how to incorporate Alismatis Rhizoma into a broader, balanced treatment plan tailored to your specific needs.

Trusted source

1. https://pubmed.ncbi.nlm.nih.gov/28662316/#:~:text=Rhizoma%20Alismatis%20%28RA%29%2C%20the%20dried%20rhizome%20of%20Alisma,of%20a%20number%20of%20well-known%20Chinese%20medicinal%20preparations. ↩︎
2. https://baike.baidu.com/item/%E6%B3%BD%E6%B3%BB/16174927 ↩︎
3. 陈曦. 泽泻的研究现状与进展[J]. 中国民族民间医药, 2011, 20(9): 50-51. ↩︎
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC5107224/ ↩︎
5. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/diuretic ↩︎
6. 豆甲泰, 李胜文. 中药泽泻对心血管系统作用的发展研究[J]. 中外医疗, 2012, 31(20): 191-191. ↩︎
7. https://www.zysj.com.cn/zhongyaocai/zexie/index.html ↩︎
8. Zhou, X., Luo, J., Lin, S. et al. Efficacy of Poria cocos and Alismatis rhizoma against diet-induced hyperlipidemia in rats based on transcriptome sequencing analysis. Sci Rep 13, 17493 (2023). https://doi.org/10.1038/s41598-023-43954-6 ↩︎
9. https://m.baidu.com/bh/m/detail/ar_17878371862034795607(Wang Baokai, Deputy Chief Physician, Department of Traditional Chinese Medicine, Beijing Tiantan Hospital Affiliated to Capital Medical University) ↩︎
10. https://www.sciencedirect.com/science/article/pii/S0141813024091566 ↩︎
11. https://baike.baidu.com/item/%E8%8C%AF%E8%8B%93%E6%B3%BD%E6%B3%BB%E6%B1%A4/22538367 ↩︎
12. https://www1.ndmctsgh.edu.tw/MedChinese/Detail/C1/C0539.html ↩︎
13. http://www.a-hospital.com/w/%E6%B3%BD%E6%B3%BB ↩︎
14. https://m.baidu.com/bh/m/detail/ar_4840170375216675705(Wang Qiang, Deputy Chief Physician, Department of Traditional Chinese Medicine, Shandong Provincial Hospital) ↩︎
15. 王琳, 魏丽凤. 泽泻的毒副作用及在肾病中的合理应用 [J/OL] . 中华肾病研究电子杂志, 2019, 08(5) : 197-200. DOI: 10.3877/cma.j.issn.2095-3216.2019.05.002. ↩︎
16. https://koreascience.kr/article/JAKO201614734909193.page ↩︎